Silver nanospheres yog cytotoxic thiab genotoxic rau ntses hlwb

Sau: Mark J. Spalding, John Pierce Wise Sr., Britton C. Goodale, Sandra S. Wise, Gary A. Craig, Adam F. Pongan, Ronald B. Walter, W. Douglas Thompson, Ah-Kau Ng, AbouEl- Makarim Aboueissa, Hiroshi Mitani, thiab Michael D. Mason
Lub npe luam tawm: Aquatic Toxicology
Tshaj tawm Hnub: Thursday, Plaub Hlis 1, 2010

Nanoparticles tau raug tshawb xyuas dav dav rau ntau yam kev siv vim lawv lub cev tshwj xeeb. Piv txwv li, nyiaj nanoparticles yog siv nyob rau hauv cov khoom lag luam rau lawv cov tshuaj tua kab mob thiab tshuaj tua kab mob. Qee yam ntawm cov khoom no yuav ua rau cov nyiaj nanoparticles ncav cuag cov dej hauv dej. Yog li ntawd, nanoparticles ua rau muaj kev txhawj xeeb txog kev noj qab haus huv rau tib neeg thiab cov tsiaj hauv dej. Peb siv medaka (Oryzias latipes) kab ntawm tes los tshawb xyuas cov cytotoxicity thiab genotoxicity ntawm 30 nm txoj kab uas hla nyiaj nanospheres. Kev kho mob ntawm 0.05, 0.3, 0.5, 3 thiab 5 μg / cm2 induced 80, 45.7, 24.3, 1 thiab 0.1% ciaj sia taus, feem, nyob rau hauv ib tug colony forming assay. Silver nanoparticles kuj induced chromosomal aberrations thiab aneuploidy. Kev kho mob ntawm 0, 0.05, 0.1 thiab 0.3 μg / cm2 cuam tshuam kev puas tsuaj hauv 8, 10.8, 16 thiab 15.8% ntawm metaphases thiab 10.8, 15.6, 24 thiab 24 tag nrho aberrations hauv 100 metaphases, feem. Cov ntaub ntawv no qhia tau hais tias nyiaj nanoparticles yog cytotoxic thiab genotoxic rau ntses hlwb.

Nyeem daim ntawv ntawm no