Awọn nanospheres fadaka jẹ cytotoxic ati genotoxic si awọn sẹẹli ẹja

Awọn onkọwe: Mark J. Spalding, John Pierce Wise Sr., Britton C. Goodale, Sandra S. Wise, Gary A. Craig, Adam F. Pongan, Ronald B. Walter, W. Douglas Thompson, Ah-Kau Ng, AbouEl- Makarim Aboueissa, Hiroshi Mitani, ati Michael D. Mason
Orukọ Atejade: Aquatic Toxicology
Ọjọ Itẹjade: Ọjọbọ, Oṣu Kẹrin Ọjọ 1, Ọdun 2010

Awọn ẹwẹ titobi ti wa ni iwadii jakejado fun ọpọlọpọ awọn ohun elo nitori awọn ohun-ini alailẹgbẹ wọn. Fun apẹẹrẹ, awọn ẹwẹ titobi fadaka ni a lo ni awọn ọja iṣowo fun awọn ohun-ini antibacterial ati antifungal wọn. Diẹ ninu awọn ọja wọnyi ṣee ṣe lati ja si ni awọn ẹwẹ titobi fadaka de agbegbe agbegbe omi. Bii iru bẹẹ, awọn ẹwẹ titobi jẹ ibakcdun ilera fun awọn eniyan ati awọn eya inu omi. A lo medaka (Oryzias latipes) laini sẹẹli lati ṣe iwadii cytotoxicity ati genotoxicity ti 30 nm diamita fadaka nanospheres. Awọn itọju ti 0.05, 0.3, 0.5, 3 ati 5 μg/cm2 fa 80, 45.7, 24.3, 1 ati 0.1% iwalaaye, ni atele, ni ileto ti o ṣẹda. Awọn ẹwẹ titobi fadaka tun fa aberrations chromosomal ati aneuploidy. Awọn itọju ti 0, 0.05, 0.1 ati 0.3 μg/cm2 fa ibajẹ ni 8, 10.8, 16 ati 15.8% ti metaphases ati 10.8, 15.6, 24 ati 24 lapapọ aberrations ni 100 metaphases, lẹsẹsẹ. Awọn data wọnyi fihan pe awọn ẹwẹ titobi fadaka jẹ cytotoxic ati genotoxic si awọn sẹẹli ẹja.

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