He cytotoxic a genotoxic nā nanosphere kala i nā pūnaeau iʻa

Nā mea kākau: Mark J. Spalding, John Pierce Wise Sr., Britton C. Goodale, Sandra S. Wise, Gary A. Craig, Adam F. Pongan, Ronald B. Walter, W. Douglas Thompson, Ah-Kau Ng, AbouEl- Makarim Aboueissa, Hiroshi Mitani, a me Michael D. Mason
Inoa Hoʻolaha: Aquatic Toxicology
Ka lā i hoʻolaha ʻia: Pōʻalima, ʻApelila 1, 2010

Ke noiʻi nui ʻia nei nā nanoparticles no nā ʻano noiʻi ma muli o ko lākou mau waiwai kino. No ka laʻana, hoʻohana ʻia nā nanoparticles kālā i nā huahana pāʻoihana no kā lākou mau waiwai antibacterial a antifungal. Hiki paha i kekahi o kēia mau huahana ke loaʻa nā nanoparticles kālā i ke kaiapuni wai. No laila, ʻo nā nanoparticles kahi pilikia olakino no ke kanaka a me nā ʻano wai. Ua hoʻohana mākou i kahi laina kelepona medaka (Oryzias latipes) e noiʻi i ka cytotoxicity a me ka genotoxicity o 30 nm anawaena kālā nanospheres. Hoʻomaʻamaʻa o 0.05, 0.3, 0.5, 3 a me 5 μg / cm2 i hoʻokomo ʻia i 80, 45.7, 24.3, 1 a me 0.1% ola, i loko o kahi koloni e hana ana i ka assay. Ua hoʻokomo pū nā nanoparticles kala i nā aberrations chromosomal a me aneuploidy. ʻO ka mālama ʻana o 0, 0.05, 0.1 a me 0.3 μg / cm2 i hōʻino ʻia i ka 8, 10.8, 16 a me 15.8% o nā metaphases a me 10.8, 15.6, 24 a me 24 ka nui o nā aberrations i 100 metaphases, kēlā me kēia. Hōʻike kēia mau ʻikepili he cytotoxic a genotoxic nā nanoparticle kālā i nā pūnaeau iʻa.

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